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The Spoon

Daily news and analysis about the food tech revolution

UPSIDE Foods

Alt Protein Enters New Era as USDA Approves Sale of Cultivated Chicken By UPSIDE & GOOD Meat

Today marks a big day for cultivated meat as two companies, UPSIDE Foods and Good Meat, announced today that they had received approval from the U.S. Department of Agriculture (USDA) to sell their cultivated meat products to consumers.

According to UPSIDE, the news came in the form of notification from the USDA that they have received a “grant of inspection” (GOI) from USDA, which means the company has met the applicable federal requirements and standards to operate as a meat establishment and is allowed to process, package, and sell our cultivated chicken in the United States under the inspection of USDA’s Food Safety and Inspection Service.

UPSIDE says that with this news, they have passed all three of the requisite milestones necessary to sell its meat – 1) “No Questions” Letter from FDA — November 2022, 2) USDA Label Approval — June 2023, and 3) today’s GOI notification.

With the latest news, the company says they are starting manufacturing of meat and scaling up production at their EPIC facility. They plan to start selling the meat soon at San Francisco’s Bar Crenn through their partnership with 3-Michelin Star chef Dominique Crenn.

Not to be outdone, GOOD Meat – the cultivated meat division of Eat Just – plans to sell its first cultivated meat in the U.S. through a partnership with Chef José Andrés. According to the company, the sale of their cultivated meat product was greenlighted with the news that the USDA has given the company approval for its first poultry product to enter interstate commerce in the U.S. According to GOOD Meat, the sale of its product will take place at a yet-to-be-disclosed restaurant in Washington, D.C.

For GOOD Meat, the news marks the second country approval for the company will begin selling its cultivated meat product. The company achieved a global first in late 2020 by selling its cultivated chicken in Singapore.

Today’s news is truly a watershed event for the alt protein space. After billions of dollars spent across the industry for research and development, commercialization, and production, we will finally see the first cultivated products sold to U.S. consumers.

However, despite today’s news, everyday consumers may still have a bit of a wait. Cultivated meat products are still being made in small quantities and will first be sold in the most exclusive of restaurants, and it might be a while before we see it at the corner grocery store.

UPSIDE’s New Investment Dollars Pushes The Company To the Front of the Cultivated Meat Line

Picture this: It’s late 2023, or perhaps 2024. Renowned Austin pitmaster and entrepreneur Aaron Franklin finishes up tending to his smokers after a long night of preparing to feed the onslaught of barbeque fans. Those queued up along Branch Street in East Austin are in for a surprise; that day, instead of the usual prime brisket rubbed with Aaron’s secret coffee-based rub, the star of the day is meat that comes from a place other than a ranch and slaughterhouse. Welcome to the world of cultivated meat.

In such a scenario, UPSIDE Foods is likely to be at the forefront of cultivated meat choices for restaurants and later consumers. Armed with an additional $400 Million in Series C financing, the Berkeley, Calif.-based company is among the leaders in the cultivated meat, poultry, and seafood industry. With these new funds, UPSIDE (formerly Memphis Meats), reaches the milestone of a $1 billion valuation. The funds will be used to expand its production footprint, additional R&D for the next generation of products, consumer education, and enhance its supply chain.

Yes, it is a gamble to fund companies in the cultivated meat space given the lack of governmental approval in the form of the FDA and USDA. Amy Chen, UPSIDE’s COO, admits she has no crystal ball, regarding when cultivated meat will get the green light in the U.S., but is confident the market demand will encourage governments-not just in the U.S.—to provide thoughtful oversight without becoming a roadblock.

“We have had years of extensive dialogue and collaboration with the regulators,” Chen told The Spoon in a recent interview. “We are fully confident that globally there is a market for it and there are eager governments that will pursue it.”

The Series C round is co-led by Temasek, a global investment company headquartered in Singapore, and the Abu Dhabi Growth Fund (ADG), a new investor. Other new investors include Baillie Gifford, Givaudan, John Doerr, SALT fund, and Synthesis Capital. They are joined by existing investors Bill Gates, Cargill,  Cercano Management, CPT Capital, Dentsu Ventures, Singapore-based global investor EDBI, Kimbal and Christiana Musk, Norwest Venture Partners, SoftBank Vision Fund 2, SOSV’s Indie Bio, and Tyson Foods.

Chen is especially proud of the large cross-section of investors that represent varied interests from venture firms to companies entrenched in the agricultural space that produce conventional meat and poultry. It is that wide range of support, she believes, that will help in consumer education as well as a long-term presence in the new food chain.

That said, there’s a lot of work that goes into convincing consumers to bite into a new type of food that is, to say the least, unconventional. Chen suggests that there is a group of early adopters in place ready to sample something new that offers a premium taste while providing the start of a solution to creating a more sustainable global food supply.

“When I think about the adoption of any new technology,” UPSIDE’s COO commented, “There are always the cutting-edge early adopters. Folks who have two characteristics – one is they love food and are open to the next thing in food with an openness to innovation and new things. The other trait is being aware and an interested in addressing some of the challenges of conventional meats.”

The bottom line for Chen is the fact that her company’s cultivated meat has the taste of the real thing. “One of the things I am super passionate about, coming from the food world, is the taste of the Product,” she said.  “Ultimately, if it doesn’t taste good when the consumer puts it into their mouth, we have lost the journey.”

UPSIDE is not alone in this quest to bring cultivated meat to the masses. There’s Brazil’s JBS, Israel’s SuperMeat, GOOD Meat, and Mosa Meats, just to name a few. There are also other companies offering technology to aid in the process that facilitates the cultivation process. According to the Good Food Institute, 21 new companies in the cultivated meat space launched in 2021, a 32% increase from the previous year.

 Approval from the FDA comes in the form of a “no questions” letter from the FDA, followed by the USDA’s investment in plant inspection and labeling guidelines. Beyond those hurdles, there are other questions: will cultivated meat be considered Kosher/Halal (given there is no ritual slaughter)? And how will this new product be merchandised in stores? Does it belong in the current meat section alongside 80/20 ground round? Lastly, how will vegans react? No animal is killed, so how will those avoiding all things steak, hamburgers, et al react?

Only time will tell.

UPSIDE Foods Adds Cell-Cultured Seafood to the Menu With Acquisition of Cultured Decadence

Today UPSIDE Foods announced they have acquired Cultured Decadence. The deal adds cell-cultured seafood products, including lobster and other crustaceans, to the UPSIDE portfolio.

Cultured Decadence, which was a Smart Kitchen Summit Startup Show finalist in 2020, was founded in Milwaukee the same year and will remain in the midwest, serving as UPSIDE’s ‘midwest hub.’

The news comes just a couple of months after the opening of UPSIDE’s flagship scale-up production facility in Berkeley. While the company has announced that cultivated chicken will be its first commercially available product, they have made it clear that their new facility will be able to produce a variety of different cell-cultured animal products.

“Seafood has a rich and delicious culinary tradition that makes it a favorite across the globe,” said Dr. Uma Valeti, Founder and CEO of UPSIDE Foods. “Cultured Decadence’s technology is incredibly promising, and their team is filled with passionate, smart individuals who want to make our favorite food a force for good. We’re thrilled to welcome the Cultured Decadence team to the UPSIDE family and are excited that the scientific, technological, and production infrastructure we have built over many years can help accelerate the mission impact of this team.”

One factor that may have made Cultured Decadance attractive – outside of the addition of cell-cultured seafood to the UPSIDE’s portfolio – is the difference in regulatory oversite in the US between seafood and poultry. The USDA and the FDA struck an agreement early on that the USDA will oversee the labeling framework for livestock and poultry, while the FDA will be the sole body regulating food products made with fish (except, for some reason, catfish, which the USDA oversees). Not only has the FDA had a year’s head start on the USDA in seeking public comments for the labeling of cell-cultured products, but some in the industry believe that the FDA might provide an easier regulatory glide path towards commercial availability when it comes to cultivated meat products.

Outside of regulatory considerations, it’s likely that UPSIDE’s development of its cell-cultured poultry products is further along than the much younger – and smaller – Cultured Decadence’s products, which may still require some significant cell-line development. UPSIDE has already had tastings of its products and they have been working towards commercial scale-up in their new flagship facility.

Finally, the acquisition by UPSIDE could also be an early sign of forthcoming consolidation by cell-cultured meat companies. Guessing by size of some of the recent funding rounds (including UPSIDE’s), it’s clear that the cost of bringing a cell-cultured meat product to scale will likely be in the tens to hundreds of millions, and at some point, it makes more sense for companies in this space to leverage existing investment in pilot and scale-up production infrastructure.

UPSIDE Foods Develops Animal-Free Cell Growth Medium

If you want to grow a cell-based steak, you’ll need a good growth medium — a nutrient-rich soup that feeds the cells as they proliferate. We’ve written previously about the cell-based meat industry’s push to ditch fetal bovine serum, a growth medium extracted from cow fetuses, and develop animal-free alternatives. By cutting animal inputs, companies can cut the costs of cell-cultivated meats, as well as the products’ environmental footprints.

Californian cell-based startup UPSIDE Foods switched away from fetal bovine serum years ago, and set a research and development team to the task of developing an alternative medium with zero animal inputs. Last week, the company announced that it has achieved that milestone, converting to an animal-free medium.

“Since day one, we knew that developing animal component-free cell feed would be crucial to fully realizing our vision of meat that’s better for the planet and its inhabitants,” company founder and CEO Dr. Uma Valeti said in a press release. “Cell feed is among the biggest drivers of cost and environmental footprint for the cultivated meat industry, and optimizing it is key to maximizing our positive impact. Our ultimate goal is to remove animals from our meat production process entirely.”

UPSIDE has used its animal-free medium to grow cell-cultivated chicken nuggets and hot dogs, demonstrating the versatility of the substrate. The company plans to grow all of its products with the new medium in future.

The achievement will help UPSIDE to scale as the company moves toward commercialization. Last month, the company unveiled its new production and development facility in Emeryville, Calif. The facility can produce 50,000 pounds of meat per year, and the company plans to boost that capacity to 400,000 pounds over time. Commercialization is still on hold as the industry waits for the USDA and FDA to create a regulatory framework — but with lower costs and increased capacity, UPSIDE is poised to take its products to the public.

San Francisco Restaurant to Serve UPSIDE Foods’ Cultivated Chicken

Berkeley, California-based cultivated meat company UPSIDE Foods, announced today that it has partnered with Dominique Crenn, the co-owner and chef of the three Michelin-starred Atelier Crenn restaurant in San Francisco. Crenn will assist with recipe development for the company, and, pending regulatory review and approval, will serve UPSIDE’s cultivated chicken at her restaurant in the future.

Previously known as Memphis Meats, UPSIDE Foods unveiled its first cultivated meatball in 2016 and its first cultivated piece of poultry in 2017. This past May, the company announced that its first consumer-facing product will be cultivated chicken. However, none of UPSIDE’s wares are on sale yet, since the company has yet to gain regulatory approval to sell these and other cultivated meat products.

At the moment, Singapore is the only country that has approved the sale of cultivated meat, and it isn’t clear who will be the next. In the U.S., the FDA and USDA will oversee the regulation of cultured meat, and figuring out this framework is still a work in progress. As a result, UPSIDE’s restaurant partnership won’t come to fruition until the company gets regulatory approval to sell its cultivated meat.

If and when that happens, it will be a big switch for Crenn’s restaurant, too. Because of environmental concerns around the production of meat, Crenn made the decision to remove all meat from Crenn Dining Group’s restaurants in 2019. Since UPSIDE’s cultivated chicken is actual meat made from harvested animal cells, the restaurant group will be deviating from that stance for the first time in a few years. Of course, one of the benefits touted by cultured meat industry is that its products are more environmentally friendly than conventionally raised meat, since no animals are slaughtered in the process.

Putting cultured meat on a restaurant menu is one way to introduce it to consumers. Other food tech start-ups like Impossible Foods and Meati have presented their products through restaurants first, before going diectly to consumers. This is one way to garner interest from the innovators and early adopters who are eager to try new products.

After getting regulatory approval, UPSIDE Foods will continue to partner with other chefs and restaurants throughout the U.S. The company has begun building a production facility in the San Francisco Bay Area, and eventually plans to roll out its cultivated meat in grocery stores.

Memphis Meats Re-Brands as UPSIDE Foods, Announces Cultured Chicken as its First Product

Memphis Meats, one of the older cell-based protein startups, announced today that it has rebranded and is now UPSIDE Foods. Perhaps more important, the company also announced that its first consumer product, cultured chicken, will be available to customers this year… pending regulatory approval.

Founded in 2015, UPSIDE Foods cultivates animal protein without the need to raise animals. The company is working on cell-based versions of different kinds of meat, but said in today’s press announcement that it chose chicken as its first product because of its versatility in recipes and culinary applications, as well as its appeal across geographic regions.

To make its cell-basd meat at scale, UPSIDE has broken ground on a production facility in the San Francisco Bay Area. The full-stack facility will produce, package and ship cultured meat at what the company says is a larger capacity than any other cell-based meat company.

Back in 2019, UPSIDE told The Spoon that the company was holding off on establishing a concrete launch date for their cultivated meat until they could guarantee their product was tasty and scalable, and until regulatory frameworks were established. This last bit was echoed in today’s press release with the “pending regulatory approval” caveat. So far, Singapore is the only country that has approved the sale of cultured meat. There hasn’t been as much clarity here in the U.S., though execs at cultured meat startups are hopeful approvals will be granted in the next two years.

We are definitely entering into a new phase in the evolution of cultured meat. A number of cell-based startups around the world have received funding this year, including CellulaRevolution, CellMeat, Mirai Foods and New Age Meats. In addition to more funding, UPSIDE and other established cultured protein startups like BlueNalu and Avant Meats are opening up their own production facilities to scale up the manufacturing of their meat.

It’s also worth noting that UPSIDE’s chicken announcement comes during the same week that Future Meat said it has dropped the production price of its cell-based chicken by 50 percent. In an interview with Plant Based News, Future Meat CEO, Rom Kshuk said it now costs $4 to produce 110 grams of its chicken, and that price should drop to $2 over the next year and a half. Reaching price parity with conventional animal meat will be a key factor in the success of cultured meat.

Along with a new identity, UPSIDE also announced a new investor today. Whole Foods CEO, John Mackey, has invested an undisclosed sum in UPSIDE.

UPSIDE’s new name and look also reflects the company moving into its own next phase as it advances beyond research and into commercial production. If you’re interested in seeing how it all began with the company, I recommend watching the documentary Meat the Future, which chronicles the rise of Memphis Meats from its very early days through much of its growth.

Meat The Future (2020) I Official Trailer I MetFilm Sales