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Washington State University Receives First-Ever FDA Approval for Gene-Edited Pigs for Human Consumption

by Michael Wolf
May 11, 2023May 11, 2023Filed under:
  • News
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Earlier this month, Washington State University (WSU) received the first-ever approval from the U.S. Food and Drug Administration for gene-edited pigs for human consumption.

That consumption will be delivered in the form of German-style sausage, which will be used in on-campus catering services that raise funds for the WSU meat judging team. The pigs were processed at the WSU Meat Lab – WSU is a land-grant university, and much of the research on campus is focused on agriculture and nature sciences – and during the processing of the meat, the U.S. Department of Agriculture inspected the meat.

The approval marks the first time the U.S. FDA has approved a gene-edited pig for entry into the food supply chain. The approval is the culmination of two years of research led by Jon Oatley, a professor in WSU’s School of Molecular Biosciences in WSU’s College of Veterinary Medicine.

“The original intent in making these animals was to try to improve the way that we feed people,” he said. “And we can’t do that unless we can work with the FDA system to get these animals actually into the food chain.”

Oatley used CRISPR gene-editing technology to improve genetic traits in the livestock. As readers of the Spoon know, CRISPR accelerates the process through which changes to an organism’s DNA can occur as compared to other methods such as through selective breeding. And unlike transgenics (or what is often called GMO or genetic modification), CRISPR doesn’t introduce genetic materials from other organisms.

Oatley and his team gene-edited the pigs to enable them to sire offspring with traits from another male pig. This technique, called surrogate sires, allows the male animals to produce sperm carrying the genetic traits of donor animals. The surrogate sires are first edited to be sterile by knocking out their specific gene related to male fertility. From there, the animals are implanted with another male pig’s stem cells to create sperm with the desired traits of the donor male.

The long-term goal for Oatley and other CRISPR researchers is to use this high-tech form of selective breeding to disseminate valuable genetic traits in livestock. Those traits could be improved meat quality, higher protein density, disease resistance, or enhanced ability to withstand changing environmental conditions.

Oatley and his team used the investigational food use authorization process for five gene-edited pigs to demonstrate that food made from the gene-edited animals is safe to eat and is now working toward FDA approval for a line of gene-edited pigs. The pigs’ offspring, which aren’t gene-edited, have not yet received FDA approval at this point for human consumption.


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Tagged:
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